IL6 and glioblastoma: Kaplan-Meier analysis of showed 5 of them such as Apoptosis, Coagulation, Hypoxia, EMT and IL6 JAK STAT3 signaling were associate with poor prognosis in GBM (Supplementary Figure S6) These results revealed the developmental trajectory of the malignant cells in GBM, and the transition of malignant cells may conduct variety clinical outcome.