Next, the RSF analysis and Multivariate Cox regression analysis were applied to screen 15 of them to construct the tumor progress-related gene risk score (TPRGRS), namely MDK, NBEAL1, HOXA2, HOXA7, MTRF1L, EREG, EN1, HOXA5, SLC37A3, LAP3, ERP29, AUTS2, HSPA5, SLC6A6 and ARMC10(Figures 6A, B). The gene discussed is LAP3; the disease is neoplasm.