Next, the RSF analysis and Multivariate Cox regression analysis were applied to screen 15 of them to construct the tumor progress-related gene risk score (TPRGRS), namely MDK, NBEAL1, HOXA2, HOXA7, MTRF1L, EREG, EN1, HOXA5, SLC37A3, LAP3, ERP29, AUTS2, HSPA5, SLC6A6 and ARMC10(Figures 6A, B). This evidence concerns the gene HOXA2 and neoplasm.