In pancreatic cancer, EV-specific GPC1 (glypican-1) and a miRNA signature (high miR-10b, miR-21, miR-30c, and miR-181a and low miR-let7a) can reliably detect early pancreatic cancer and have been shown to be superior to the standard CA 19-9 plasma test (21, 22). This evidence concerns the gene GPC1 and familial pancreatic carcinoma.