This suggests that different cell types have different sensitivities towards these inhibitors, which may be explained by differential expression levels of Rac and Cdc42, as shown in Supplementary Figure 3 where equal protein concentrations (25mg) from macrophage or breast cancer lysates with equal actin staining show double the concentration of Cdc42 in macrophages, compared to triple negative breast cancer (TNBC) cells. The gene discussed is AKT1; the disease is breast cancer.