Of those collagens that were differentially regulated, all were down-regulated in patient-derived tumour samples compared to matched non-tumour samples, ranging from 1.7-fold for type I collagen α1 chain (COL1A1) to 18.1-fold for type VI collagen α6 chain (COL6A6) (Supplementary Figure 2; Supplementary Data 3). Here, COL1A1 is linked to neoplasm.