Matrisome proteins up-regulated in tumours were enriched for protein hydroxylation processes (Supplementary Data 5), driven by procollagen-lysine,2-oxoglutarate 5-dioxygenases (also known as lysyl hydroxylases) and prolyl 3- and prolyl 4-hydroxylases (Supplementary Figure 2; Supplementary Data 3), which formed a functional subnetwork of interacting proteins (Figure 3A; Supplementary Figure 3A). The gene discussed is PLOD2; the disease is neoplasm.