IL13RA2 and glioblastoma: Furthermore, notably, in another study, intracavitary infusion of IL13Rα2-directed CAR-T cells followed by additional doses of intracerebroventricular infusion via lateral ventricles caused a noteworthy objective intracranial and spinal response in a patient at a late stage of multifocal GBM with a persistent clinical response for 7.5 months (1, 15).