In fact, while CAR-T cell activation is associated with massive release of inflammatory cytokines, such as IL-1, IL-2, IL-6, IL-10, IL-15 and tumor necrosis factor alpha (strictly associated with the development of CRS and ICANS), CAR NK cells release different type of cytokines, such as IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) (59). This evidence concerns the gene IFNG and congenital rubella syndrome.