Gsc+/Cyp26A1 mice develop overtly normal through adulthood, with one notable exception: between days 60 and 75 postnatally (PN60-75) they developed an irregular alignment of the teeth known as severe craniofacial maxillary malocclusions, caused by uneven teeth wear or a misalignment of the jaw (Figures 8B, E, F) (Diagnosis | Severe prognathic malocclusion, 2007). Here, GSC is linked to Dental malocclusion.