This aberrant Trigeminal cranial nerve Gsc+/Cyp26A1 phenotype is reminiscent of HoxA1 and HoxB1 knock-out mice as well as the LgDel mouse model of 22q11.2 Deletion Syndrome (Gavalas et al., 1998; Karpinski et al., 2014). Here, GSC is linked to 22q11.2 deletion syndrome.