CSK and colitis: Mechanistically, this CSK-dependent pathogenesis of DSS-induced colitis involves activation of Src in the absence of CSK, which followed by the phosphorylation and subsequent proteasomal degradation of occludin, leads to the increased intercellular permeability of the IECs (Samak et al., 2015; Imada et al., 2016; Chelakkot et al., 2017) (Figure 2).