YAP1 and metabolic dysfunction-associated steatohepatitis: It has been found that YAP expression is significantly increased in Kupffer cells (KCs) from wild-type mice fed a high-fat diet (HFD), and analysis of liver tissue from NASH pa-tients shows that YAP is increased in KCs, and a positive correlation exists between YAP levels and pro-inflammatory cytokines in human liver tissue, and Kupffer cells (KCs) produce pro-inflammatory cytokines when YAP is activated and promotes the development of nonalcoholic steatohepatitis (NASH) (Song et al., 2020).