IL13 and neoplasm: M2 TAMs are generally anti-inflammatory and pro-tumoural, expressing IL-10, IL-13, MR (mannose receptor) and are capable of inducing humoral Th2-driven cytokine responses, secreting IL-4, IL-13 and high levels of chemokines and growth factors such as VEGF, TGF-β, FGF and uPA, promoting angiogenesis, immunosuppression, tumour invasion and metastasis (14, 15).