IGFBP3 encrypts a protein with an IGFBP domain and a thyroglobulin type-I domain and forms a ternary complex with insulin-like growth factor acid-labile subunit (Shahjee et al., 2008), which plays a prominent role in tumor proliferation suppression (Huynh et al., 2002) and apoptosis induction (Rajah, Valentinis & Cohen, 1997). This evidence concerns the gene IGFBP3 and neoplasm.