Recent reports suggest that RGS2 participation in a hepatitis B virus-related gene model is very useful in differentiating liver cancer patients with different prognoses (Wang et al., 2022), while ENO2 has also participated in the construction of multiple prognostic models of liver cancer, such as hypoxia-related prognostic models (Tang et al., 2022; Wang et al., 2021) and metabolism-related prognostic models (Lee et al., 2022). The gene discussed is RGS2; the disease is liver cancer.