Parallel to our findings in the HFD-induced NASH mice, we observed a significant increase in the protein expression of Lp-PLA2, p-mTOR/mTOR, p-JAK2/JAK2, and p-STAT3/STAT3 in Kupffer cells from the NASH group compared to normal cells (P < 0.001). The gene discussed is JAK2; the disease is metabolic dysfunction-associated steatohepatitis.