MTOR and metabolic dysfunction-associated steatohepatitis: Of note, we found that rapamycin (a mTOR inhibitor for promoting autophagy) treatment presented similar effects as Lp-PLA2 silencing on alleviating liver injury, inflammation, lipid and collagen accumulation in HFD-induced NASH mice, additionally, rapamycin markedly enhanced the effects of Lp-PLA2 silencing.