PLA2G7 and metabolic dysfunction-associated steatohepatitis: Colak et al. (2012) suggested that Lp-PLA2 expression is upregulated in NAFLD including NASH, which is closely associated with histological steatosis scores in patients. Sun et al. (2017) revealed that the reduction of macrophage Lp-PLA2 can mitigate the inflammatory cell infiltration in liver tissues from mice.