Bi et al. (2018) reported that the inhibition of JAK2/STAT3 pathway suppressed inflammation and hepatocyte steatosis in Kupffer cells (resident liver macrophages) with NAFLD. Chen & Liu (2018) found that actein ameliorated hepatic steatosis and fibrosis in HFD-induced NAFLD via inhibiting JAK2/STAT3 signal. Zhang et al. (2006) discovered that rapamycin suppressed JAK2/STAT3 pathway to reduce inflammation induced by acute liver injury. Here, JAK2 is linked to metabolic dysfunction-associated steatotic liver disease.