study by Zhang et al. indicated that oral administration of D. fimbriatum extracts at the doses of 100 and 200 mg/kg (orally, 2 to 5 weeks) significantly ameliorated diabetes symptoms via inhibiting the inflammatory factors such as cytokines IL-1β and TNF-α and preventing islet cell apoptosis in diabetic rats. The gene discussed is IL1B; the disease is diabetes mellitus.