GCG and Hyperglycemia: Liu et al. investigated the antidiabetic effects of polysaccharides from D. officinale and observed that an intraperitoneal administration of the ethanolic extract of the stem (100, 200, and 400 mg/kg, 4 weeks) to STZ-HFD-induced diabetic mice ameliorated hyperglycemia and hepatic glucose metabolism through regulating the liver-glycogen structure and glucagon-mediated signaling pathways.