The search keywords included “anti-hyperglycemic”, “antihypertensive”, “antidiabetic”, “atherosclerosis”, “obesity”, “blood pressure”, “blood glucose”, “Dendrobium”, “diabetes”, “dyslipidemia”, “high cholesterol”, “hypercholesterolemia”, “hyperglycemic”, “hyperlipidemia”, “body mass index”, “waist circumference”, “hypertension”, hypertriglyceridemia”, “hypoglycemic”, “hypotensive”, “insulin”, “insulin-resistance”, “metabolic syndrome”, “triglyceride”, “atherogenic” and “ weight loss”. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.