We selected only one gene polymorphism rs4880 (Figure 3F) of SOD2 which included 545 NIHL cases and 1038 control cases to analyze, using random effect model, no significant correlation was found (OR 1.187; 95% CI 0.846–1.666) and no publication bias was observed (t = 0.95; p = 0.517) (Supplementary Figure S4A). Here, SOD2 is linked to noise induced hearing loss.