AIF1 and neurodegenerative disease: P2RY12 was decreased in the spinal cord of mutant SOD1 mice that mimicked amyotrophic lateral sclerosis pathology, although Iba-1-positive microglia were increased, indicating that the loss of microglia homeostatic genes might be involved in microglial dysfunction in neurodegenerative diseases (Butovsky et al., 2015).