The pathophysiological mechanism of hair loss induced by psychological stress may be associated with the upregulation of corticotropin-releasing hormone receptor (CRHR), adrenocorticotropin (ACTH), and acetylcholine (ACh) in the skin, which regulate immunity, promote cytokine secretion, and lead to the collapse of HF-IP (56–58). Here, POMC is linked to hydrops fetalis.