Likewise, our previous study (14) enrolled 619 postmenopausal women with T2DM revealed that monocyte to APOA1 ratios had a higher area under the curve (AUC) value in identifying osteoporosis than the monocyte to HDL-c ratios, which indicate us that serum APOA1 may be more associated with osteoporosis rather than serum HDL-c. This evidence concerns the gene APOA1 and type 2 diabetes mellitus.