A significant association between osteoporosis and APOA1 was also observed after additional adjustment for HbA1c, TG, HDL-c, APOA1, LDL-c, creatinine, ALT, UA, and HOMA-IR (model 2), and the ORs (95%CI) was 0.843 (0.782–0.910) respectively. The gene discussed is GPT; the disease is osteoporosis.