Furthermore, MR analyses between TIM-3 and five additional immunologic diseases (systemic lupus erythematosus, psoriasis, rheumatoid arthritis, multiple sclerosis, and juvenile idiopathic arthritis) do not support a causal association of TIM-3 with the risk of these immune diseases (Supplementary Tables S1, S2). Here, HAVCR2 is linked to rheumatoid arthritis.