Mercury, especially MeHg, has a high affinity for —SH groups and selenium, which reduces antioxidant defense by disrupting GSH, GPX, and catalase and promotes free radical-mediated oxidative stress and lipid peroxidation [66], [191] It can promote atherosclerosis by inhibiting NF-κB activation by lipid peroxidation or by binding to the —SH groups present in NF-κB. This evidence concerns the gene NFKB1 and atherosclerosis.