DTNBP1 and schizophrenia: Rather, there remain several high-risk genes that contribute to the hypofunction of NMDAR to increase the susceptibility to SZ, including neuregulin 1 (NRG1; Roy et al., 2007; Mei and Xiong, 2008; Kato et al., 2011), disrupted in schizophrenia-1 (DISC-1; Lipina et al., 2010; Niwa et al., 2010), and dystrobrevin-binding protein 1 (dysbindin-1; Ji et al., 2009; Papaleo and Weinberger, 2011; Papaleo et al., 2012).