CRY1 and sleep disorder: Clock genes exhibit a robust correlation with DSWPD, particularly, CRY1. A case report has demonstrated that mutations identified in the exon 11 allele of CRY1 extend the duration of circadian molecular rhythms, thereby delaying both sleep onset and wakefulness, ultimately leading to the beginning of DSWPD, a phenomenon characterized by individuals who habitually go to bed late and wake up late—commonly referred to as “night owls.” This sleep disorder may also possess a genetic predisposition (33).