Recently defined, BPAN is the only X-linked subtype of neurodegeneration with brain iron accumulation (NBIA) due to a de novo mutation in the WD repeat domain 45 (WDR45) gene at the Xp11.23 locus, which is responsible for encoding a beta-propeller scaffold protein, hence the name BPAN [1,2]. This evidence concerns the gene WDR45 and neurodegeneration with brain iron accumulation.