ABCB1 and Alzheimer disease: Pan et al. used human brain microvascular endothelial cells derived exosomes inheriting p-glycoprotein as an Aβ cleansing system to remove Aβ peptides from the brain by specific capture between p-glycoprotein and Aβ, which can facilitate the clearance of Aβ and effectively ameliorate the cognitive dysfunction of AD mice (Pan et al., 2020).