Studies have assessed the effects of AL002a/c, a humanized monoclonal IgG1 antibody that binds to TREM2 and activates the TREM2 signaling pathway, and 4D9 on Aβ accumulation in transgenic AD mouse models (Price et al., 2020; Schlepckow et al., 2020; Wang S. et al., 2020). Here, TREM2 is linked to Alzheimer disease.