Notably, increased RIPK1 kinase activity has been observed in animal models of AD, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), as well as in human patient samples, implying a potential contribution of this protein to the pathogenesis of these neurodegenerative disorders (Yuan et al., 2019). This evidence concerns the gene RIPK1 and amyotrophic lateral sclerosis.