MAPT and Alzheimer disease: The conjecture underpinning microglial depletion is that certain activated microglia, including DAM, may accentuate AD pathogenesis through a series of actions, such as facilitating the accumulation of Aβ plaques, amplifying neuroinflammation, and potentially influencing tau pathology (Keren-Shaul et al., 2017; Krasemann et al., 2017).