In addition, microglia can activate inflammasome-related signaling upon Aβ binding, resulting in the activation of IL-1β and IL-18 through the NLR family pyrin domain containing 3 (NLRP3)/apoptosis-associated speck-like protein containing a CARD (ASC)/Caspase1 pathway, thereby contributing to the pathological progression of AD via detrimental inflammatory responses (Yang Y. et al., 2019; Zhao et al., 2020b). This evidence concerns the gene NLRP3 and Alzheimer disease.