Another CD33 SNP, rs2455069, has been proposed to be associated with AD susceptibility, with in silico analysis suggesting that an amino acid switch at position 69 of hCD33 from an arginine to glycine in the rare rs2455069 SNP may enhance the affinity for sialic acid-containing ligands (Tortora et al., 2022). This evidence concerns the gene CD33 and Alzheimer disease.