ALB and atrial fibrillation: Reduced eGFR and elevated urine albumin-to-creatinine ratio were significantly associated with greater risk of incident AF. There was a stepwise increase in the adjusted risk of incident AF across categories of decreasing eGFR. The greatest risk was among participants with an eGFR <30 ml/min per 1.73 m2. Meta-analysis of JHS and MESA, revealed a stepwise association between higher UACR and risk of incident AF, with the greatest risk among participants with UACR 300 mg/g (hazard ratio, 1.76; 95% confidence interval, 1.18 to 2.62) compared with those with UACR<15 mg/g.