SLC5A2 and type 2 diabetes mellitus: In a substudy of the EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes) trial (95, 96) the HF benefits from use of the SGLT2 inhibitor empagliflozin, including early signs or symptoms of HF were consistent whether or not AF was present at baseline.