SAA2 and Crohn disease: From an extensive panel of inflammatory markers, including CRP, IL-22, and IL-6, SAA had among the highest positive associations with a Simplified Endoscopy Score for CD (SES-CD, r = 0.4), fecal calprotectin (r = 0.39), Crohn's Disease Activity Index (CDAI, r = 0.14), and stool frequency (r = 0.18) (223).