CDKN2B-AS1 and myocardial infarction: CDKN2B-AS1 (also known as ANRIL) binds PRC1 and PRC2 to regulate chromatin methylation, leading to silencing of the INK4b-ARF- ANRIL has been identified as a genetic risk factor for coronary artery disease, and its expression levels correlate with left ventricular dysfunction after myocardial infarction (69, 72).