The myocardial infarction area was significantly reduced in rats with myocardial infarction injected with KLF3-AS1 exosome, and the expressions of NLRP3, caspase-1, GSDMD, IL-1β and IL-18 in KLF3-AS1-overexpressed myocardial infarction mice were also significantly decreased. The gene discussed is GSDMD; the disease is myocardial infarction.