For example, oxidized low-density lipoprotein (Ox-LDL)-induced endothelial cell pyroptosis can cause abnormal endothelial proliferation and vascular stenosis; oxidative stress (60), NLRP3 inflammatory vesicles and lncRNA-mediated pyroptosis can contribute to the formation of myocardial fibrosis (61); IL-1β and IL-18-mediated pyroptosis responses directly lead to myocardial hypertrophy, ventricular hypertrophy and myocardial ischemia and hypoxia in diabetic patients (62). This evidence concerns the gene NLRP3 and myocardial ischemia.