Furthermore, in multivariate analysis adjusting for age, sex, BMI, diabetes, hs-CRP, tertile of serum miR-183-5p levels showed increased predictive value on the presence of CAD (middle vs. low tertile, HR 3.81, 95% CI 1.07–13.56, p = 0.039; high vs. low tertile, HR 14.57, 95% CI 1.38–153.65, p = 0.026; p for trend = 0.024) and 3-vessel or LM disease (middle vs. low tertile, HR 2.11, 95% CI 0.46–9.70, p = 0.34; high vs. low tertile, HR 6.59, 95% CI 1.59–27.25, p = 0.009; p for trend = 0.020) (Table 3). This evidence concerns the gene CRP and diabetes mellitus.