The main findings of the present study included: (1) a significant step-wise increased pattern existed between the Gensini score tertiles and serum miR-183-5p levels; (2) serum miR-183-5p levels were positively correlated with the Gensini score and hs-CRP; (3) serum miR-183-5p levels could predict CAD presence and severity, with optimal cut-off values of 1.40 (sensitivity 82.6%, specificity 70.0%) and 3.65 (sensitivity 54.2%, specificity 88.3%), respectively; (4) the predictive value of serum miR-183-5p levels on CAD presence and severity were confirmed in multivariable analysis. The gene discussed is CRP; the disease is coronary artery disorder.