To examine the role of STAT4 in myeloid cells during advanced atherosclerosis, we successfully generated myeloid-specific (Stat4ΔLysMLdlr−/−), neutrophil-specific (Stat4ΔS100A8Ldlr−/−), and Stat4-sufficient floxed control (Stat4fl/flLdlr−/−) mice. Here, STAT4 is linked to atherosclerosis.