LRRK2 and Parkinson disease: Its multiple roles include participation in vesicle sorting by mediating the endosomal-autophagic pathway and late endosomal membrane trafficking.29, 30, 31 Over 40 missense mutations in LRRK2 have been identified,11 all of them displaying an autosomal dominant PD pattern, of which G2385R variant (rs34778348) confers a risk for people to develop PD in Asia.32