To further study whether S100a8 and a9 gene expression at the early stage of bacteremia can predict the later development of septic arthritis, we compared mRNA levels of S100a8 and a9 on day 2 after infection between mice infected with Newman WT strain and mice infected with ΔsrtA/B strain. This evidence concerns the gene IGKV1D-22 and bacterial infectious disease with sepsis.