Aberrant alterations of S100a8/a9 are well noted for many diseases including cancer (Duan et al., 2013; Kwon et al., 2013; Koh et al., 2019), cardiovascular (Boyd et al., 2008; Sreejit et al., 2019), skin diseases (Schonthaler et al., 2013), autoimmune disorders (Ometto et al., 2017; Vogl et al., 2018; Defrêne et al., 2021), infections (Scott et al., 2020), and many more (van Lent et al., 2010; Wang et al., 2014). This evidence concerns the gene S100A8 and autoimmune disease.