KRT88P and hepatocellular carcinoma: High viral load (HVL) (HBV DNA≥8 log10 copies/mL), positive HBeAg, slightly liver inflammation (Anti-HBc <3 log10 IU/mL), low-risk of fibrosis progression and HCC development, all these suggested that these particular PV patients may be in the immune tolerance phase (Sarin et al., 2016; European Association for the Study of the Liver, 2017; Terrault et al., 2018).