As neutrophil accumulation into areas characterized by molecular and microenvironmental structural anomaly is a function mainly of the balance of CXCR2 and CXCR4 ligands and the neutrophil cell surface ratio of CXCR2:CXCR4 chemokine receptors (76), modulation of signaling via these receptors was proposed to be potentially therapeutic for T2D progression, IR, and possibly NAFLD. Here, CXCR4 is linked to type 2 diabetes mellitus.