In the present work, we examined the acute (in response to injection of positron-emitting zinc) and chronic (assessing endogenous levels) handling of zinc in wild-type mice and in an R138X mouse model that mimics the human SLC30A8 LoF mutation (p.Arg138*) associated with lowered T2D risk (4–6). Here, SLC30A8 is linked to type 2 diabetes mellitus.