On the other hand, an important and dose-dependent increase in serum insulin level was observed with glibenclamide (p < 0.05) and AERS at 50 (p < 0.05), 100 (p < 0.01), and 200 mg/kg (p < 0.001), compared to untreated T1D rats (Fig. 3B). This evidence concerns the gene INS and type 1 diabetes mellitus.