Frequent drinkers [OR (95% CI) = 2.34 (1.15–4.77)] and never drinkers [OR (95% CI) = 2.08 (1.05–4.13)] had higher risk of mild cognitive impairment than infrequent drinkers; APOE4 presence enhanced the risk of dementia with increasing alcohol drinking [OR (95% CI) infrequent drinkers = 4.08 (0.98–16.91); OR (95% CI) frequent drinkers = 7.07 (1.37–36.60)]. Here, APOE is linked to Cognitive impairment.