CD274 and cancer: Finally, it is important to recognise the role that these cells play as mechanisms of resistance against anti-PD-1/anti-PD-L1 therapies and how possible combinations of treatments could help to obtain better results, such as anti-PD-1/anti-PD-L1 therapies associated with anti-angiogenic therapy used in different types of cancer according to certain molecular characteristics that promote their use, however, it is necessary to develop prospective studies that allow us to evaluate the role of these cells as biomarkers of response and selection of treatments in different types of neoplasms.