Similarly, CCR5 antagonists also inhibited the potential spread of triple-negative breast cancer and promoted decreased tumour growth; another important receptor is CSF-1R: which is a receptor tyrosine kinase that, when bound to its ligand CSF-1, promotes MDSC migration, differentiation and expansion of myeloid cells into MDSCs as well as TAMs. This evidence concerns the gene CSF1 and triple-negative breast carcinoma.