Partially mature dendritic cells in peripheral blood of PAAD patients, significantly enhanced the expressions of CD83, CD40, B7H3, PDL-1, CCR6 and CCR7, decreased the expressions of ICOSL and DCIR, and improved the survival and prognostic outcomes of patients (Tjomsland et al., 2010). This evidence concerns the gene CD276 and pancreatic adenocarcinoma.