Partially mature dendritic cells in peripheral blood of PAAD patients, significantly enhanced the expressions of CD83, CD40, B7H3, PDL-1, CCR6 and CCR7, decreased the expressions of ICOSL and DCIR, and improved the survival and prognostic outcomes of patients (Tjomsland et al., 2010). Here, ICOSLG is linked to pancreatic adenocarcinoma.