However, T-cells from Apolipoprotein e deficient (Apoe−/−) mice with advanced atherosclerosis due to 20 weeks of cholesterol-rich Western-type diet (WTD) feeding, show decreased T-cell proliferation and increased T-cell apoptosis compared to T-cells from Apoe−/− mice fed a chow diet [25•]. Here, APOE is linked to atherosclerosis.