No tumours were observed in the SI, stomach, liver, hepato-biliary tract, pancreas, spleen, lymph nodes or thymus in any of the induced or non-induced, water-treated or ethanol-treated Aldh1b1flox/flox Msh2-LS and Aldh1b1−/− Msh2-LS mice. The gene discussed is MSH2; the disease is neoplasm.