Ethanol-treated induced Aldh1b1−/− Msh2-LS colonic adenomas showed widespread variably high p53 expression (Fig. 2O) reflecting the ‘wild-type pattern’ in response to ethanol-induced genotoxic damage (Köbel et al., 2016; Lakin and Jackson, 1999). This evidence concerns the gene MSH2 and colon adenoma.