MSH2 and neoplasm: IHC of cCas3 showed significantly higher numbers of cCas3+ apoptotic bodies in the ethanol-treated induced Aldh1b1−/− Msh2-LS non-tumour-bearing colon compared with no or almost no detectable cCas3+ apoptotic bodies in the water-treated induced Aldh1b1−/− Msh2-LS colon (P=0.0026, unpaired two-tailed Student's t-test) (Fig. 2K,L, Fig. 3L).