This was also observed in ethanol-treated induced Aldh1b1flox/flox Msh2-LS murine colonic adenomas (Fig. S5E,F), indicating activation of the Wnt signalling pathway in these adenomas, compared with very low levels of nuclear β-catenin expression in the normal mucosal epithelium (Fig. S11). The gene discussed is MSH2; the disease is colon adenoma.