LGR5 and colonic neoplasm: We also showed that ethanol can accelerate colonic tumour formation in a mouse model of LS (Lgr5-CreER; Msh2flox/−), known as Msh2-LS, involving scattered foci of intestinal conditional inactivation of MSH2 function (by tamoxifen-induced transient Cre activation) in LGR5-expressing intestinal epithelial stem cells (Barker et al., 2007; Claij and te Riele, 2004; de Wind et al., 1995; Wojciechowicz et al., 2014; Cerretelli et al., 2021).