MSH2 and neoplasm: Although the patterns of tumour distribution were similar, the numbers of tumours per tumour-bearing mouse were statistically significantly greater in both ethanol-treated induced Aldh1b1flox/flox Msh2-LS and ethanol-treated induced Aldh1b1−/− Msh2-LS mice compared with those in ethanol-treated induced Aldh1b1wt Msh2-LS mice (Fig. 1E; Fig. S4A-D) (previous data from Cerretelli et al., 2021).