In the ethanol-treated induced Aldh1b1−/− Msh2-LS mice, 8/12 (66.7%) demonstrated large intestinal epithelial hyperproliferation with colonic adenoma formation, all within an average of 6 months (Fig. 1B; Fig. S3A-D), but no adenocarcinomas were observed. Here, MSH2 is linked to adenocarcinoma.