Also, as the SIRS response is defined as a result of systemic immunological activation, DAG-deepVASE uniquely found nonlinear associations between SIRS status and proinflammatory cytokines, including C-reactive protein (CRP) [73, 74], IL-1β [75], and interferon γ (IFN-γ) [76] (Fig. 3B), corroborating their collective roles in inflammation. The gene discussed is CRP; the disease is systemic inflammatory response syndrome.