With respect to the cancer milieu, treatments that ensure a shift toward the anti‐tumor CD4+ T helper 1 (Th1) response are essential, while maintaining a low T helper 2 (Th2) response is critical to ensure a tumor‐specific immune response.[29] Therefore, we detected different CD4+ T cell populations in the spleens of the vaccinated mice. The gene discussed is CD4; the disease is cancer.