As FANCD2 is expressed -albeit not monoubiquitinated- in the FA fibroblasts used in this work, we cannot exclude that the delay of monoadduct repair in HeLa FANCD2 KO cells could also represent a non-canonical function of unmodified FANCD2 in promoting the repair of mono-melphalan-induced lesions. Here, FANCD2 is linked to Friedreich ataxia.