TLR8 and focal segmental glomerulosclerosis: This finding is in agreement with the previous report of restricted expression of TLR8 in the tubulointerstitial of nephropathy.[26] Second, analysis of the NephroSeq online database (GSE108112) further showed that the renal tubular TLR8 level was significantly elevated in FSGS patients (Figure S11B, Supporting Information)[31] and negatively correlated with patients’ GFR value (Figure S11C, Supporting Information).