Various TLRs are involved in the development of severe autoimmune disease and inflammation in multiple organs, including the kidney.[36, 37] TLRs can be activated by endogenous ligands released by self‐tissue or damaged cells in various disease conditions.[38] For instance, HMGB1 can activate TLR4 and induce podocyte and tubular injury.[39] However, the role of TLR7 (murine)/8 (human) in renal innate immunity and disease development is unclear. The gene discussed is HMGB1; the disease is autoimmune disease.