To elucidate the correlation between menin expression and R-loop-mediated DNA damage and genome instability in human lung cancer samples, we randomly collected 52 lung cancer specimens, histologically classified samples from 42 patients with LUAD, 8 patients with squamous carcinoma and 2 patients with lung neuroendocrine carcinoma, and corresponding adjacent non-cancerous specimens (Supplementary Table S1). The gene discussed is MEN1; the disease is squamous cell carcinoma.