The mice were sacrificed on day 14, and the tumor weight and Ki67 index of the MEN1-KO-vehicle xenograft tumors were dramatically augmented compared with these measures in the MEN1-WT-vehicle xenograft tumors; treatment with Mad reduced the tumor weight and Ki67 index, and showed higher selectivity for the MEN1-KO xenograft tumors (Figure 6F–J). This evidence concerns the gene MEN1 and neoplasm.