Indeed, the HML-2 LTR5Hs gene, which has functionality as a transcription factor binding site and genomic enhancer for downstream genes and can activate the OCT4 stem cell gene, was found in its full-length functional state in six human chromosomes that were overexpressed in stem-like GBM cells compared with more differentiated GBM tumor cells. Here, POU5F1 is linked to glioblastoma.