Moreover, those with severe COVID-19 had lower median nadir CD4+ cell count [153 (IQR 60–262) vs. 260 (130–390) cells/μl, P < 0.001] and lower median current CD4+ cell count [593 (IQR 403–830) vs. 720 (IQR 540–910) cells/μl, P < 0.001]. This evidence concerns the gene CD4 and COVID-19.