Alternatively, Duet al. [161] determined that METTL14 regulates SIRT6 in hepatoma cells by regulating m6A levels onUSP48 (ubiquitin-specific peptidase 48) mRNA; in another study, it was shown that SIRT6 protects smooth muscle cells from senescence and reduces AS. The gene discussed is SIRT6; the disease is hepatocellular carcinoma.