ADGRG6 and adolescent idiopathic scoliosis: Human mutations of ADGRG6 are also associated with hypomyelination of the PNS and are causative for a lethal contracture syndrome, arthrogryposis multiplex congenita (AMC),2, 7 while other studies have linked variants in ADGRG6 to a wide range of diseases, including adolescent idiopathic scoliosis and cancer (reviewed in Baxendale et al.8).