Among these lysosomal genes, genes encoding two established profibrogenic proteases, cathepsin B and D38, were overexpressed in Prep-/- M2-polarized BMDMs and Prep knockdown NIH-3T3 cells, and cathepsin B and D were morbidly aggregated in fibrotic regions of WD/CCl4-induced fibrotic murine liver (Figs. 6 and 7). This evidence concerns the gene PREP and Wilson disease.