LY6D and metabolic dysfunction-associated steatotic liver disease: Next, to determine the clinical relevance of Ly6d in the pathogenesis of NAFLD, we investigated whether there were histological and transcriptomic differences between the 20 subjects with the highest (high-LY6D group) and lowest (low-LY6D group) LY6D mRNA expression levels in the liver in the data from the GTEx project23.